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6737 Mowry Ave
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RPE65
retinal pigment epithelium-specific protein 65kDa
Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.
| Gene Name: | retinal pigment epithelium-specific protein 65kDa |
| Synonyms: | RPE65, LCA2, RBP-binding membrane protein, Retinol isomerase, SRPE65, Rd12, MRPE65, Retinoid isomerohydrolase, RP20 |
| Target Sequences: | NM_000329 NP_000320.1 Q16518 |
Publications (18)
1
Aging enhances pressure-induced arterial superoxide formation. Jacobson A, Yan C, Gao Q, Rincon-Skinner T, Rivera A, Edwards J, Huang A, Kaley G, Sun D. American journal of physiology. Heart and circulatory physiology. 2007 293:H1344-50.
[PubMed:17557915]
2
Human cone photoreceptor dependence on RPE65 isomerase. Jacobson SG, Aleman TS, Cideciyan AV, Heon E, Golczak M, Beltran WA, Sumaroka A, Schwartz SB, Roman AJ, Windsor EA, Wilson JM, Aguirre GD, Stone EM, Palczewski K. Proceedings of the National Academy of Sciences of the United States of America. 2007 104:15123-8. (WB; Human)
[PubMed:17848510]
[PMC:PMC1986623]
3
Reactivation of uveitogenic T cells by retinal astrocytes derived from experimental autoimmune uveitis-prone B10RIII mice. Jiang G, Ke Y, Sun D, Han G, Kaplan HJ, Shao H. Investigative ophthalmology & visual science. 2008 49:282-9. (ICC; Mouse)
[PubMed:18172104]
[PMC:PMC2567872]
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RPE65
(32)
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(7)
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monoclonal mc
(8)
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(14)
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401.8B11.3D9
(5)
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(6)
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(4)
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(2)
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(3)
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(4)
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(31)
Yes
(1)
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(1)
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(1)
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Neuroscience
RPE65 Mouse anti-Bovine Monoclonal (401.8B11.3D9) Antibody
Chicken, Bovine, Mouse, Dog, Rat, Pig, Human
Flo, ICC, IHC-P, WB
Unconjugated
0.2 ml/$460
RPE65 Mouse anti-Bovine Monoclonal (Biotin) (401.8B11.3D9) Antibody
Mouse, Bovine, Pig, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, WB
Biotin Conjugated
0.2 ml/$416
RPE65 Mouse anti-Bovine Monoclonal (DY650) (401.8B11.3D9) Antibody
Mouse, Bovine, Pig, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, WB
DY650 Conjugated
0.2 ml/$416
RPE65 Mouse anti-Bovine Monoclonal (DY488) (401.8B11.3D9) Antibody
Mouse, Bovine, Pig, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, WB
DY488 Conjugated
0.2 ml/$416
RPE65 Mouse anti-Bovine Monoclonal (DY550) (401.8B11.3D9) Antibody
Mouse, Bovine, Pig, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, WB
DY550 Conjugated
0.2 ml/$416
RPE65 Mouse anti-Bovine Monoclonal Antibody
Mouse, Bovine, Rat, Pig, Human
ELISA, ICC, IF, IHC, IHC-Fr, WB
Unconjugated
100 µl/$688
RPE65 Goat anti-Human Polyclonal (aa352-364) Antibody
Rabbit, Dog, Bovine, Rat, Pig, Horse, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Neuroscience
RPE65 Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, IF, IHC-P, WB
Unconjugated
50 µg/$460
RPE65 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
HRP Conjugated
50 µg/$294; 100 µg/$360
RPE65 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$294; 100 µg/$360
RPE65 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
FITC Conjugated
50 µg/$294; 100 µg/$360
RPE65 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
RPE65 Rabbit-New Zealand White anti-Mouse Polyclonal (aa490-533) Antibody
Mouse, Rat
IHC, WB
Unconjugated
100 µl/$393
RPE65 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
RPE65 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
WB
Unconjugated
100 µl/$424
RPE65 Rabbit anti-Human Polyclonal (Internal) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$469
RPE65 Rabbit anti-Human Polyclonal (Internal) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$469
RPE65 Rabbit anti-Human Polyclonal (Internal) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$469
E. coli
97 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
10.78 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
RPE65 Mouse anti-Bovine Monoclonal (Biotin) Antibody
Bovine
ICC, IHC, WB
Biotin Conjugated
200 µl/$889
RPE65 Mouse anti-Bovine Monoclonal (HRP) Antibody
Bovine
ICC, IHC, WB
HRP Conjugated
100 µl/$878
RPE65 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
RPE65 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321
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