RPA2 / RFA2 / RPA34

replication protein A2, 32kDa

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

RPA2 / RFA2 / RPA34 (5)

Publications

No (5)

Tag

GST (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human RPA2 / RFA2 / RPA34 Protein (Recombinant His) - LS-G1019

Source:

E. coli

Tag:

His

Price:

50 µg/$392; 250 µg/$872; 10 µg/$286; 20 µg/$348; 100 µg/$511; 500 µg/$1,355

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Human RPA2 / RFA2 / RPA34 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78608

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.1 kDa

Price:

20 µg/$150

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Human RPA2 / RFA2 / RPA34 Protein (Recombinant GST) (Full Length) - LS-G30195

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

55.44 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RPA2 / RFA2 / RPA34 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66856

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.1 kDa

Price:

20 µg/$1,107

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RPA2 / RFA2 / RPA34 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99916

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.1 kDa

Price:

100 µg/$494

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