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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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ROS1 / ROS
c-ros oncogene 1 , receptor tyrosine kinase
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
| Gene Name: | c-ros oncogene 1 , receptor tyrosine kinase |
| Family/Subfamily: | Protein Kinase , Ros/Sevenless |
| Synonyms: | ROS1, C-ros-1, c-ros, C-Ros receptor tyrosine kinase, MCF3, Proto-oncogene c-Ros, Proto-oncogene c-Ros-1, ROS |
| Target Sequences: | NM_002944 NP_002935.2 P08922 |
Publications (2)
1
Attenuation of hepatic ischemia-reperfusion injury by adipose stem cell-derived exosome treatment via ERK1/2 and GSK-3ß signaling pathways. Yaqing Zhang , Yonghua Li , Qilong Wang , Dongyu Zheng, Xue Feng, Wei Zhao, Linlin Cai, Qingqing Zhang, Haitao Xu, Hailong Fu. International journal of molecular medicine. 2022 February;49:13. [Full Text Article]
[PubMed:34878156]
[PMC:PMC8711591]
2
Carissa macrocarpa Leaves Polar Fraction Ameliorates Doxorubicin-Induced Neurotoxicity in Rats via Downregulating the Oxidative Stress and Inflammatory Markers. Mohamed A A Orabi, Heba M A Khalil, Mohamed E Abouelela, Dalia Zaafar, Yasmine H Ahmed, Reham A Naggar, Hamad S Alyami, El-Shaymaa Abdel-Sattar, Katsuyoshi Matsunami, Dalia I Hamdan. Pharmaceuticals (Basel, Switzerland). 2021 December;14:1305. [Full Text Article]
[PubMed:34959705]
[PMC:PMC8709457]
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ROS1 / ROS
(48)
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(12)
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(8)
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monoclonal mc
(20)
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1843CT776.78.21
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(47)
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(1)
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(1)
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(2)
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(2)
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(1)
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(2)
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$730
Cancer Pathology
Cancer
ROS1 / ROS Rabbit anti-Rat Polyclonal (aa1937-2210) Antibody
Rat
IHC-P, WB
Unconjugated
50 µl/$460
Cancer Pathology
Cancer
ROS1 / ROS Rabbit anti-Human Polyclonal (aa1744-1777) Antibody
Human
IHC-P, WB
Unconjugated
200 µl/$460
ROS1 / ROS Mouse anti-Human Monoclonal (aa2126-2347) (OTI1F3) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
ROS1 / ROS Mouse anti-Human Monoclonal (aa2126-2347) (Carrier-free) (OTI1F3) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ROS1 / ROS Rabbit anti-Human Monoclonal (EPMGHR2) Antibody
Human
IHC
Unconjugated
6 ml/$945
ROS1 / ROS Mouse anti-Human Monoclonal Antibody
Human
WB
Unconjugated
100 µl/$314; 200 µl/$359; 500 µl/$507; 1 ml/$581; 2 ml/$798; 5 ml/$1,296
ROS1 / ROS Mouse anti-Human Monoclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$325; 200 µl/$373; 500 µl/$536; 1 ml/$628; 2 ml/$860; 5 ml/$1,425
ROS1 / ROS Goat anti-Human Polyclonal (aa2307-2318) Antibody
Human
Peptide-ELISA
Unconjugated
100 µg/$401
ROS1 / ROS Rabbit anti-Human Polyclonal (aa23-56) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
200 µl/$568
ROS1 / ROS Mouse anti-Human Monoclonal (aa2126-2347) (OTI1E6) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
ROS1 / ROS Mouse anti-Human Monoclonal (aa2126-2347) (Carrier-free) (OTI1E6) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ROS1 / ROS Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ROS1 / ROS Mouse anti-Human Monoclonal (1843CT776.78.21) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$393
ROS1 / ROS Rabbit anti-Human Polyclonal Antibody
Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ROS1 / ROS Mouse anti-Human Monoclonal (aa2126-2347) (OTI5D2) Antibody
Human
WB
Unconjugated
100 µl/$434
ROS1 / ROS Mouse anti-Human Monoclonal (aa2126-2347) (Carrier-free) (OTI5D2) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ROS1 / ROS Mouse anti-Human Monoclonal (aa1882-2125) (OTI1A1) Antibody
Human
WB
Unconjugated
100 µl/$450
ROS1 / ROS Mouse anti-Human Monoclonal (aa1882-2125) (Carrier-free) (OTI1A1) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ROS1 / ROS Mouse anti-Human Monoclonal (aa2126-2347) (OTI7E4) Antibody
Human
WB
Unconjugated
100 µl/$434
ROS1 / ROS Mouse anti-Human Monoclonal (aa2126-2347) (Carrier-free) (OTI7E4) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ROS1 / ROS Rabbit anti-Human Polyclonal (pTyr2114) Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$328; 100 µl/$419
ROS1 / ROS Rabbit anti-Human Polyclonal (aa1945-2222) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
ROS1 / ROS Rabbit anti-Human Polyclonal (pTyr2114) Antibody
Chicken, Bovine, Rabbit, Mouse, Rat, Pig, Human
WB
Unconjugated
100 µl/$315
ROS1 / ROS Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P
Unconjugated
100 µg/$357
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