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RORB / ROR Beta
RAR-related orphan receptor B
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity.
| Gene Name: | RAR-related orphan receptor B |
| Family/Subfamily: | NHR , NR1 Thyroid hormone-like |
| Synonyms: | RORB, BA133M9.1, Nuclear receptor ROR-beta, NR1F2, ROR Beta, ROR-BETA, Rorbeta, RZR-BETA, Nuclear receptor RZR-beta, RAR-related orphan receptor B, RZRB |
| Target Sequences: | NM_006914 NP_008845.2 Q92753 |
Publications (1)
1
Transient microglial absence assists postmigratory cortical neurons in proper differentiation. Yuki Hattori, Yu Naito, Yoji Tsugawa, Shigenori Nonaka, Hiroaki Wake, Takashi Nagasawa, Ayano Kawaguchi, Takaki Miyata. Nature communications. 2020 Apr;11:1631. [Full Text Article]
[PubMed:32242005]
[PMC:PMC7118101]
Related Antibodies: LS-A2374.
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Neuroscience
RORB / ROR Beta Rabbit anti-Human Polyclonal (Ligand-binding Domain) Antibody
Chicken, Sheep, Bovine, Rat, Hamster, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Neuroscience
Fast Shipping
RORB / ROR Beta Rabbit anti-Human Polyclonal (Hinge Domain) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
RORB / ROR Beta Rabbit anti-Human Polyclonal (Hinge Domain) Antibody
Chicken, Sheep, Bovine, Rat, Hamster, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
RORB / ROR Beta Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
RORB / ROR Beta Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$469
RORB / ROR Beta Rabbit anti-Human Polyclonal (aa329-358) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
RORB / ROR Beta Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
RORB / ROR Beta Mouse anti-Human Monoclonal (aa1-260) (OTI1G1) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
RORB / ROR Beta Mouse anti-Human Monoclonal (aa1-260) (Carrier-free) (OTI1G1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
RORB / ROR Beta Rabbit anti-Human Polyclonal (aa329-358) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
RORB / ROR Beta Rabbit anti-Human Polyclonal (aa329-358) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
RORB / ROR Beta Rabbit anti-Human Polyclonal (aa329-358) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
RORB / ROR Beta Rabbit anti-Human Polyclonal (aa329-358) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
RORB / ROR Beta Rabbit anti-Human Polyclonal (aa329-358) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
RORB / ROR Beta Rabbit anti-Human Polyclonal (aa329-358) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
RORB / ROR Beta Mouse anti-Human Monoclonal (4B4) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
RORB / ROR Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
RORB / ROR Beta Rabbit anti-Mouse Polyclonal (aa86-135) Antibody
Mouse
WB
Unconjugated
100 µl/$424
RORB / ROR Beta Mouse anti-Human Monoclonal (aa1-260) (OTI1B6) Antibody
Human
WB
Unconjugated
100 µl/$434
RORB / ROR Beta Mouse anti-Human Monoclonal (aa1-260) (Carrier-free) (OTI1B6) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
RORB / ROR Beta Mouse anti-Human Monoclonal (aa1-260) (OTI4B12) Antibody
Human
WB
Unconjugated
100 µl/$434
RORB / ROR Beta Mouse anti-Human Monoclonal (aa1-260) (OTI4B7) Antibody
Human
WB
Unconjugated
100 µl/$434
RORB / ROR Beta Mouse anti-Human Monoclonal (aa1-260) (Carrier-free) (OTI4B7) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
RORB / ROR Beta Mouse anti-Human Monoclonal (aa1-260) (OTI1C11) Antibody
Human
WB
Unconjugated
100 µl/$434
RORB / ROR Beta Mouse anti-Human Monoclonal (aa1-260) (Carrier-free) (OTI1C11) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
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