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E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
Gene Name: | ring finger protein (C3H2C3 type) 6 |
Synonyms: | RNF6, SPG2, RING-H2 protein RNF-6 |
Target Sequences: | NM_005977 NP_005968.1 Q9Y252 |
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