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RNF40 / STARING
Ring finger protein 40, E3 ubiquitin protein ligase
Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.
| Gene Name: | Ring finger protein 40, E3 ubiquitin protein ligase |
| Synonyms: | RNF40, BRE1-B, KIAA0661, RING finger protein 40, Rb-associated protein, STARING, BRE1B, RBP95 |
| Target Sequences: | NM_014771 NP_055586.1 O75150 |
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