RNF4

Ring Finger Protein 4

E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

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Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

RNF4 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His-GST, N-terminus (1)

Myc-DDK (Flag) (4)

Species

Human (5)

Mouse (1)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

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Human RNF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79695

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.8 kDa

Price:

20 µg/$150

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Human RNF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79696

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.1 kDa

Price:

20 µg/$150

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RNF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117657

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.1 kDa

Price:

100 µg/$494

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RNF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G129396

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.8 kDa

Price:

100 µg/$494

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Mouse RNF4 Protein (Recombinant His-GST, N-terminus) (Met1-Ile194) - LS-G133253

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

51.9kDa

Price:

10 µg/$244; 50 µg/$295; 200 µg/$422; 100 µg/$345; 1 mg/$1,200; 500 µg/$842; 5 mg/$2,040; 2 mg/$1,345

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Human RNF4 Protein (Recombinant GST) (Full Length) - LS-G30186

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

47.7 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RNF4 Protein (Recombinant GST, N-terminus) (aa107-190) - LS-G59923

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RNF4 Protein (Recombinant His) - LS-G1977

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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