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Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator.
Gene Name: | ring finger protein 20, E3 ubiquitin protein ligase |
Synonyms: | RNF20, BRE1, BRE1-A, HBRE1, KAIA2779, RING finger protein 20, BRE1A, Homolog of S. cerevisiae BRE1 |
Target Sequences: | NM_019592 NP_062538.5 Q5VTR2 |
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