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E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells.
Gene Name: | ring finger protein 19B |
Synonyms: | RNF19B, IBRDC3, IBR domain containing 3, NKLAM, Ring finger protein 19B |
Target Sequences: | NM_001127361 NP_001120833.1 Q6ZMZ0 |
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