RNF146

ring finger protein 146

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation By similarity. Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

RNF146 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

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Purified (1)

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RNF146 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109320

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.6 kDa

Price:

100 µg/$494

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Human RNF146 Protein (Recombinant His, N-Terminal) - LS-G144750

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

38.6 kDa

Price:

50 µg/$419

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Human RNF146 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87689

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.6 kDa

Price:

20 µg/$150

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Human RNF146 Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G63290

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RNF146 Protein (Recombinant GST) (Full Length) - LS-G35538

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

65.2 kDa

Price:

10 µg/$479; 25 µg/$670

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