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E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
Gene Name: | ring finger protein 144B |
Synonyms: | RNF144B, BA528A10.3, IBRDC2, p53RFP, IBR domain containing 2, PIR2, Ring finger protein 144B |
Target Sequences: | Q7Z419 Q7Z419 |
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