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E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.
Gene Name: | ring finger protein 138, E3 ubiquitin protein ligase |
Synonyms: | RNF138, HNARF, HSD-4, RING finger protein 138, STRIN |
Target Sequences: | NM_016271 NP_057355.2 Q8WVD3 |
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