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E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.
Gene Name: | ring finger protein 114 |
Family/Subfamily: | Zinc Finger |
Synonyms: | RNF114, PSORS12, Ring finger protein 114, Zinc finger protein 313, ZNF228, ZNF313, Zinc finger protein 228 |
Target Sequences: | NM_018683 NP_061153.1 Q9Y508 |
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