RNF11

Ring Finger Protein 11

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

RNF11 (6)

Publications

No (6)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (2)

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Human RNF11 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69303

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.3 kDa

Price:

20 µg/$1,107

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RNF11 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101205

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.3 kDa

Price:

100 µg/$494

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Human RNF11 Protein (Recombinant 6His, N-terminus) (aa2-154) - LS-G57247

Source:

Yeast

Tag:

6His, N-terminus

Price:

1 mg/$1,607; 100 µg/$469; 20 µg/$349

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Human RNF11 Protein (Recombinant GST, N-terminus) (aa65-154) - LS-G62210

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RNF11 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84304

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.3 kDa

Price:

20 µg/$150

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Human RNF11 Protein (Recombinant GST) (Full Length) - LS-G33225

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

42.68 kDa

Price:

10 µg/$479; 25 µg/$670

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