RNASEL / RNase L

ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)

Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.

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ELISA Kits (1)

Type

Sandwich (1)

Target

RNASEL / RNase L (1)

Reactivity

Human (1)

Format

96-Well Strip Plate (1)

Publications

No (1)

Sample Type

Plasma (1)

Serum (1)

Tissue Homogenates (1)

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Human RNASEL / RNase L (Sandwich ELISA) ELISA Kit - LS-F7656

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.63 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$730

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