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RNASEL / RNase L
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.
| Gene Name: | ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) |
| Family/Subfamily: | Protein Kinase , Provisional Protein Kinase |
| Synonyms: | RNASEL, 2-5A-dependent ribonuclease, 2-5A-dependent RNAase, 2-5A-dependent RNase, HPC1, PRCA1, RNS4, RNase L, Prostate cancer 1, Ribonuclease 4, Ribonuclease L |
| Target Sequences: | NM_021133 NP_066956.1 Q05823 |
Publications (8)
1
2-5A-dependent RNase molecules dimerize during activation by 2-5A. Dong B, Silverman RH. The Journal of biological chemistry. 1995 270:4133-7.
[PubMed:7876164]
2
A bipartite model of 2-5A-dependent RNase L. Dong B, Silverman RH. The Journal of biological chemistry. 1997 272:22236-42. (WB; Human)
[PubMed:9268370]
3
Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis. Wang L, Zhou A, Vasavada S, Dong B, Nie H, Church JM, Williams BR, Banerjee S, Silverman RH. Clinical cancer research : an official journal of the American Association for Cancer Research. 1995 1:1421-8.
[PubMed:9815940]
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RNASEL / RNase L
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RNASEL / RNase L Rabbit anti-Mouse Polyclonal (aa140-167) Antibody
Mouse
WB
Unconjugated
400 µl/$393
RNASEL / RNase L Mouse anti-Human Monoclonal (2E9) Antibody
Hamster, Primate, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$375
RNASEL / RNase L Mouse anti-Human Monoclonal (Biotin) (2E9) Antibody
Human, Primate
ELISA, IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
RNASEL / RNase L Mouse anti-Human Monoclonal (DY650) (2E9) Antibody
Human, Primate
ELISA, IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
RNASEL / RNase L Mouse anti-Human Monoclonal (DY488) (2E9) Antibody
Human, Primate
ELISA, IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
RNASEL / RNase L Mouse anti-Human Monoclonal (DY550) (2E9) Antibody
Human, Primate
ELISA, IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$730
HEK 293 Cells
Myc-DDK (Flag)
83.4 kDa
100 µg/$710
RNASEL / RNase L Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
RNASEL / RNase L Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
RNASEL / RNase L Rabbit anti-Mouse Polyclonal (aa140-167) Antibody
Mouse
ELISA, WB
Unconjugated
200 µl/$734
RNASEL / RNase L Rabbit anti-Mouse Polyclonal (aa140-167) (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
200 µl/$952
RNASEL / RNase L Rabbit anti-Mouse Polyclonal (aa140-167) (FITC) Antibody
Mouse
ELISA, WB
FITC Conjugated
200 µl/$952
RNASEL / RNase L Rabbit anti-Mouse Polyclonal (aa140-167) (APC) Antibody
Mouse
ELISA, WB
APC Conjugated
200 µl/$952
RNASEL / RNase L Rabbit anti-Mouse Polyclonal (aa140-167) (PE) Antibody
Mouse
ELISA, WB
PE Conjugated
200 µl/$952
RNASEL / RNase L Rabbit anti-Mouse Polyclonal (aa140-167) (Azide-free) (HRP) Antibody
Mouse
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
RNASEL / RNase L Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
RNASEL / RNase L Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
RNASEL / RNase L Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
RNASEL / RNase L Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
RNASEL / RNase L Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
RNASEL / RNase L Mouse anti-Human Monoclonal (3B4) Antibody
Human
ELISA
Unconjugated
100 µg/$335
RNASEL / RNase L Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
RNASEL / RNase L Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
30 µl/$266; 50 µl/$286; 100 µl/$321; 200 µl/$386
RNASEL / RNase L Rabbit anti-Human Polyclonal (aa358-583) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
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