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RIPK3 / RIP3

receptor-interacting serine-threonine kinase 3

Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Gene Name: receptor-interacting serine-threonine kinase 3
Family/Subfamily: Protein Kinase , RIP
Synonyms: RIPK3, Receptor interacting protein 3, RIP-like protein kinase 3, RIP3, RIP-3, Receptor-interacting protein 3
Target Sequences: NM_006871 NP_006862.2 Q9Y572

Publications (2)

1
The effects and regulatory mechanism of RIP3 on RGC-5 necroptosis following elevated hydrostatic pressure. Shang L, Ding W, Li N, Liao L, Chen D, Huang J, Xiong K. Acta biochimica et biophysica Sinica. 2017 February;49:128-137. [Full Text Article] [PubMed:28039150] Related Antibodies: LS-C97217.
2
A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2a-induced corpus luteum regression. Dianrong Li, Jie Chen, Jia Guo, Lin Li, Gaihong Cai, She Chen, Jia Huang, Hui Yang, Yinhua Zhuang, Fengchao Wang, Xiaodong Wang. eLife. 2021 May;10: [Full Text Article] [PubMed:34029184] [PMC:PMC8143796] Related Antibodies: LS-C336804.

☰ Filters
Products
Proteins (11)
Recombinant (11)
RIPK3 / RIP3 (11)
No (11)
10His, N-terminus + Myc, C-terminus (1)
6His, N-terminus (2)
6His-SUMO, N-terminus (1)
GST (1)
GST, N-terminus (3)
GST, N-terminus + His, C-terminus (1)
His-T7 (2)
Human (8)
Mouse (2)
Rat (1)
Baculovirus (1)
E. coli (4)
Sf9 Cells (2)
Wheat Germ Extract (2)
Yeast (2)
Purified (4)
RIPK3 / RIP3 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
RIPK3 / RIP3 Protein
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Yeast
6His, N-terminus
55.32 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
RIPK3 / RIP3 Protein - Recombinant Receptor Interacting Serine Threonine Kinase 3 By SDS-PAGE
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E. coli
His-T7
28.5 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
RIPK3 / RIP3 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Baculovirus
10His, N-terminus + Myc, C-terminus
100 µg/$1,067; 20 µg/$447; 1 mg/$1,988
RIPK3 / RIP3 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
100 µg/$446; 20 µg/$336; 1 mg/$1,460
RIPK3 / RIP3 Protein - 12.5% SDS-PAGE of human RIPK3 stained with Coomassie Blue
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Wheat Germ Extract
GST
82.72 kDa
2 µg/$439
RIPK3 / RIP3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
2 µg/$439
RIPK3 / RIP3 Protein
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E. coli
GST, N-terminus + His, C-terminus
84.7 kDa
50 µg/$419
RIPK3 / RIP3 Protein
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Sf9 Cells
GST, N-terminus
56.7 kDa
20 µg/$677
RIPK3 / RIP3 Protein
Select
Sf9 Cells
GST, N-terminus
56.7 kDa
20 µg/$677
RIPK3 / RIP3 Protein - Recombinant Receptor Interacting Serine Threonine Kinase 3 By SDS-PAGE
Select
E. coli
His-T7
28.1 kDa
10 µg/$283; 50 µg/$457; 100 µg/$732; 200 µg/$912; 1 mg/$2,032; 500 µg/$1,567; 5 mg/$3,193; 2 mg/$2,219
Viewing 1-11 of 11 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).