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RIPK3 / RIP3
receptor-interacting serine-threonine kinase 3
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
| Gene Name: | receptor-interacting serine-threonine kinase 3 |
| Family/Subfamily: | Protein Kinase , RIP |
| Synonyms: | RIPK3, Receptor interacting protein 3, RIP-like protein kinase 3, RIP3, RIP-3, Receptor-interacting protein 3 |
| Target Sequences: | NM_006871 NP_006862.2 Q9Y572 |
Publications (2)
1
The effects and regulatory mechanism of RIP3 on RGC-5 necroptosis following elevated hydrostatic pressure. Shang L, Ding W, Li N, Liao L, Chen D, Huang J, Xiong K. Acta biochimica et biophysica Sinica. 2017 February;49:128-137. [Full Text Article]
[PubMed:28039150]
Related Antibodies: LS-C97217.
2
A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2a-induced corpus luteum regression. Dianrong Li, Jie Chen, Jia Guo, Lin Li, Gaihong Cai, She Chen, Jia Huang, Hui Yang, Yinhua Zhuang, Fengchao Wang, Xiaodong Wang. eLife. 2021 May;10: [Full Text Article]
[PubMed:34029184]
[PMC:PMC8143796]
Related Antibodies: LS-C336804.
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(4)
RIPK3 / RIP3 Rabbit anti-Human Polyclonal (aa489-518) Antibody
Mouse, Human
IHC, WB
Unconjugated
400 µl/$393
RIPK3 / RIP3 Rabbit anti-Human Polyclonal (aa480-530) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$440
RIPK3 / RIP3 Mouse anti-Human Monoclonal (aa233-518) (OTI1B3) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
RIPK3 / RIP3 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
RIPK3 / RIP3 Mouse anti-Human Monoclonal (aa233-518) (OTI2F12) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
Yeast
6His, N-terminus
55.32 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
RIPK3 / RIP3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.1 mg/$460
RIPK3 / RIP3 Rabbit anti-Human Polyclonal (aa480-509) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
RIPK3 / RIP3 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC
Biotin Conjugated
50 µg/$294; 100 µg/$360
RIPK3 / RIP3 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC
FITC Conjugated
50 µg/$294; 100 µg/$360
RIPK3 / RIP3 Mouse anti-Human Monoclonal (aa233-518) (OTI1D9) Antibody
Human
WB
Unconjugated
100 µl/$434
E. coli
His-T7
28.5 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
RIPK3 / RIP3 Rabbit anti-Human Polyclonal (aa61-91) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
RIPK3 / RIP3 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Human
IF, IHC, WB
Biotin Conjugated
100 µg/$477
RIPK3 / RIP3 Rabbit anti-Human Polyclonal (FITC) Antibody
Mouse, Human
IF, IHC, WB
FITC Conjugated
100 µg/$473
RIPK3 / RIP3 Rabbit anti-Human Polyclonal (aa168-217) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
RIPK3 / RIP3 Rabbit anti-Human Polyclonal (aa489-518) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
RIPK3 / RIP3 Rabbit anti-Human Polyclonal (aa61-91) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
RIPK3 / RIP3 Rabbit anti-Human Polyclonal (aa61-91) (MaxLight 550) Antibody
Mouse, Human
IHC, WB
MaxLight 550 Conjugated
100 µl/$952
RIPK3 / RIP3 Rabbit anti-Human Polyclonal (aa400-450) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
RIPK3 / RIP3 Rabbit anti-Human Polyclonal (aa251-300) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
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