RIPK1 / RIP

receptor (TNFRSF)-interacting serine-threonine kinase 1

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.

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Products

ELISA Kits (6)

Type

Sandwich (6)

Target

RIPK1 / RIP (6)

Reactivity

Human (3)

Mouse (1)

Rat (2)

Format

96-Well Strip Plate (6)

Publications

No (5)

Yes (1)

Sample Type

Cell Culture Supernatants (2)

Cell Lysates (3)

Plasma (5)

Serum (5)

Tissue Homogenates (4)

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Mouse RIPK1 / RIP (Sandwich ELISA) ELISA Kit - LS-F65172

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human RIPK1 / RIP (Sandwich ELISA) ELISA Kit - LS-F9254

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$834

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Human RIPK1 / RIP (Sandwich ELISA) ELISA Kit - LS-F55576

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$792

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Rat RIPK1 / RIP (Sandwich ELISA) ELISA Kit - LS-F56081

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Rat RIPK1 / RIP (Sandwich ELISA) ELISA Kit - LS-F9518

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$783

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Human RIPK1 / RIP (Sandwich ELISA) ELISA Kit - LS-F49673

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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