RICK / RIP2

receptor-interacting serine-threonine kinase 2

Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.

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Products

Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

RICK / RIP2 (9)

Publications

No (9)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (6)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human RICK / RIP2 Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G21134

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

65.3 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human RICK / RIP2 Protein (Recombinant GST) (Full Length) - LS-G31319

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

87.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Rat RICK / RIP2 Protein (Recombinant) (Met1-Leu294) - LS-G133742

Source:

E. coli

Tag:

None

Molecular Weight:

37.5kDa

Price:

10 µg/$274; 50 µg/$400; 200 µg/$797; 100 µg/$637; 1 mg/$1,870; 500 µg/$1,424; 5 mg/$2,832; 2 mg/$2,053

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Human RICK / RIP2 Protein (Recombinant GST, N-terminus) (aa431-540) - LS-G60854

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RICK / RIP2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70874

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61 kDa

Price:

20 µg/$1,107

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Human RICK / RIP2 Protein (Recombinant His-T7) (aa432-540) - LS-G24487

Source:

E. coli

Tag:

His-T7

Molecular Weight:

16.2 kDa

Price:

10 µg/$290; 50 µg/$500; 100 µg/$797; 200 µg/$997; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329

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Mouse RICK / RIP2 Protein (Recombinant His-T7) (aa1-294) - LS-G24488

Source:

E. coli

Tag:

His-T7

Molecular Weight:

37.4 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human RICK / RIP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88199

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61 kDa

Price:

20 µg/$150

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RICK / RIP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117064

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61 kDa

Price:

100 µg/$494

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