RICK / RIP2

receptor-interacting serine-threonine kinase 2

Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.

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Products

Antibodies (71)

ELISA Kits (12)

Proteins (9)

Type

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Competitive EIA (1)

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Over-Expression Lysate (2)

Primary (71)

Recombinant (7)

Sandwich (7)

Target

RICK / RIP2 (92)

Reactivity

Human (60)

Mouse (49)

Rat (39)

Bovine (3)

Chicken (1)

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Peptide-ELISA (3)

Host

rabbit (67)

mouse (3)

rat (1)

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Isotype

IgG (34)

IgG1,k (1)

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IgG2a,k (2)

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aa1-294 (8)

aa432-540 (8)

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N-Terminal (1)

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His-T7 (2)

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Species

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Mouse (1)

Rat (1)

Source

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HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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IHC-plus™ RICK / RIP2 Antibody LS-B1394

(4.0) Rating

Antibody:

RICK / RIP2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$440

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RICK / RIP2 Antibody (clone 3D9) LS-C133570

Antibody:

RICK / RIP2 Mouse anti-Human Monoclonal (3D9) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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RICK / RIP2 Antibody (120-200 aa) LS-C381392

Antibody:

RICK / RIP2 Rabbit anti-Human Polyclonal (120-200 aa) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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Human RICK / RIP2 (Sandwich ELISA) ELISA Kit - LS-F23815

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Human RICK / RIP2 Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G21134

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

65.3 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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RICK / RIP2 Antibody (clone 6F7) LS-C133569

Antibody:

RICK / RIP2 Mouse anti-Human Monoclonal (6F7) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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RICK / RIP2 Antibody LS-C332122

Antibody:

RICK / RIP2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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RICK / RIP2 Antibody (aa458-488) LS-C97216

Antibody:

RICK / RIP2 Rabbit anti-Human Polyclonal (aa458-488) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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RICK / RIP2 Antibody (phospho-Ser176) LS-C800207

Antibody:

RICK / RIP2 Rabbit anti-Human Polyclonal (pSer176) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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Human RICK / RIP2 Protein (Recombinant GST) (Full Length) - LS-G31319

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

87.6 kDa

Price:

10 µg/$479; 25 µg/$670

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RICK / RIP2 Antibody (aa146-195) LS-C199543

Antibody:

RICK / RIP2 Rabbit anti-Human Polyclonal (aa146-195) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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RICK / RIP2 Antibody (120-200 aa) LS-C385930

Antibody:

RICK / RIP2 Rabbit anti-Human Polyclonal (120-200 aa) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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IHC-plus™ RICK / RIP2 Antibody (clone 7F5) LS-B10054

(4.0) Rating

Antibody:

RICK / RIP2 Mouse anti-Human Monoclonal (7F5) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-Fr, WB

Format:

Unconjugated

Price:

50 µg/$460

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RICK / RIP2 Antibody LS-C296

Antibody:

RICK / RIP2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, ICC, IF, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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Rat RICK / RIP2 Protein (Recombinant) (Met1-Leu294) - LS-G133742

Source:

E. coli

Tag:

None

Molecular Weight:

37.5kDa

Price:

10 µg/$274; 50 µg/$400; 200 µg/$797; 100 µg/$637; 1 mg/$1,870; 500 µg/$1,424; 5 mg/$2,832; 2 mg/$2,053

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RICK / RIP2 Antibody (aa458-488) LS-C328547

Antibody:

RICK / RIP2 Rabbit anti-Human Polyclonal (aa458-488) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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RICK / RIP2 Antibody (aa458-488, Biotin) LS-C220582

Antibody:

RICK / RIP2 Rabbit anti-Human Polyclonal (aa458-488) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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RICK / RIP2 Antibody (aa458-488, FITC) LS-C220583

Antibody:

RICK / RIP2 Rabbit anti-Human Polyclonal (aa458-488) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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RICK / RIP2 Antibody (aa458-488, APC) LS-C220580

Antibody:

RICK / RIP2 Rabbit anti-Human Polyclonal (aa458-488) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC

• Unconjugated
• Biotin
• FITC
• More...
  • APC

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RICK / RIP2 Antibody (aa432-540) LS-C374240

Antibody:

RICK / RIP2 Rabbit anti-Human Polyclonal (aa432-540) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182

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RICK / RIP2 Antibody (phospho-Ser176) LS-C825459

Antibody:

RICK / RIP2 Rabbit anti-Human Polyclonal (pSer176) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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RICK / RIP2 Antibody (p176) LS-C825460

Antibody:

RICK / RIP2 Rabbit anti-Human Polyclonal (p176) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

RICK / RIP2 Antibody LS-C318451

Antibody:

RICK / RIP2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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RICK / RIP2 Antibody (aa1-540) LS-C376497

Antibody:

RICK / RIP2 Rabbit anti-Human Polyclonal (aa1-540) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

Select

RICK / RIP2 Antibody LS-C804226

Antibody:

RICK / RIP2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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