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The G protein-coupled receptor kinases (GRKs) are important enzymes in the desensitization of activated G protein-coupled receptors (GPCR). Among these enzymes, GRK1 is involved in phototransduction and is the most specialized kinase of the family. GRK1 phosphorylates photoactivated rhodopsin (Rho*), initiating steps in its deactivation. GRK1 has been shown to be essential for normal deactivation of cone phototransduction.
Gene Name: | G protein-coupled receptor kinase 1 |
Family/Subfamily: | Protein Kinase , GPRK |
Synonyms: | GRK1, GPRK1, RK, Rhodopsin kinase, RHOK |
Target Sequences: | NM_002929 NP_002920.1 Q15835 |
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