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Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
Gene Name: | ras homolog family member B |
Family/Subfamily: | Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806 |
Synonyms: | RHOB, Aplysia RAS-related homolog 6, ARH6, H6, MST081, Oncogene RHO H6, RHOH6, Ras homolog family member B, ARHB, Transforming protein rhob, MSTP081, Rho cDNA clone 6 |
Target Sequences: | NM_004040 NP_004031.1 P62745 |
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