RHOA

ras homolog family member A

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

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Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

RHOA (9)

Publications

No (9)

Tag

6His, N-terminus (1)

GST (2)

GST, N-terminus (1)

His (1)

His,N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (8)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Insect Cells (1)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (1)

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Human RHOA Protein (Recombinant His) - LS-G1072

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human RHOA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91335

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.6 kDa

Price:

20 µg/$150

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Human RHOA Protein (Recombinant GST, N-terminus) (aa91-190) - LS-G57804

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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RHOA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99514

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.6 kDa

Price:

100 µg/$494

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Human RHOA Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72070

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.6 kDa

Price:

20 µg/$1,107

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Human RHOA Protein (Recombinant GST) (Full Length) - LS-G22077

Source:

E. coli

Tag:

GST

Molecular Weight:

48.9 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human RHOA Protein (Recombinant GST) (Full Length) - LS-G27514

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

46.97 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RHOA Protein (Recombinant His,N-terminus) (Met1-Leu193) - LS-G138006

Source:

Insect Cells

Tag:

His,N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

24 kDa

Price:

100 µg/$721

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Human RHOA Protein (Recombinant 6His, N-terminus) (Ala2-Cys190) - LS-G97042

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

26 kDa

Price:

10 µg/$265; 50 µg/$315

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