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RHOA

ras homolog family member A

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Gene Name: ras homolog family member A
Family/Subfamily: Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806
Synonyms: RHOA, ARH12, ARHA, Aplysia ras-related homolog 12, H12, Oncogene RHO H12, Rho cDNA clone 12, RHO12, RHOH12, Ras homolog family member A, Small GTP binding protein RhoA, Transforming protein RhoA
Target Sequences: NM_001664 NP_001655.1 P61586

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Products
Antibodies (41)
Primary (41)
RHOA (41)
Human (40)
Mouse (16)
Rat (15)
Bovine (1)
Dog (1)
Monkey (1)
IHC (23)
IHC-P (8)
WB (32)
Flo (4)
ELISA (22)
ICC (2)
IF (5)
IP (1)
Peptide-ELISA (3)
rabbit (30)
mouse (11)
Product Group
IHCPlus (2)
IgG (22)
IgG1 (2)
IgG1,l (7)
monoclonal mc (11)
polyclonal pc (30)
#03 (1)
09 (1)
1B12 (1)
1C1 (1)
APC Conjugated (1)
Biotin Conjugated (3)
FITC Conjugated (4)
HRP Conjugated (3)
PE Conjugated (2)
Preservative Free (2)
Unconjugated (28)
pSer188 (2)
130-210 aa (1)
Arg182 (1)
C-Terminus (1)
aa1-155 (1)
aa100-150 (1)
aa144-193 (1)
p188 (1)
No (41)
RHOA Antibody - Anti-RHOA antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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RHOA Mouse anti-Human Monoclonal (1C1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
RHOA Antibody - Anti-RHOA antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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RHOA Mouse anti-Human Monoclonal (1B12) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
RHOA Antibody - Western blot analysis of extracts of various cell lines, using RHOA antibody.
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RHOA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
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RHOA Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, ICC, IF
Unconjugated
100 µl/$412
RHOA Antibody - Western blot of RhoA phosphorylation expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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RHOA Rabbit anti-Human Polyclonal (pSer188) Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µg/$305; 100 µg/$357
RHOA Antibody - 1:100 staining human prostate tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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RHOA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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RHOA Mouse anti-Human Monoclonal (aa1-155) Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
200 µg/$984
RHOA Antibody - Rabbit antibody to RhoA (100-150). IHC on mouse brain (cryo section) using Rabbit antibody to RhoA at a concentration of 15 ug/ml, incubated overnight and developed with DAB Ni.
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RHOA Rabbit anti-Human Polyclonal (aa100-150) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
500 µg/$393
RHOA Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RHOA Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
RHOA Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RHOA Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
RHOA Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RHOA Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
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RHOA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
RHOA Antibody - Western blot of Rho A antibody
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RHOA Rabbit anti-Human Polyclonal (130-210 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
RHOA Antibody - Western blot analysis of extracts from HepG2 cells, using RhoA (Ab-188) antibody.
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RHOA Rabbit anti-Human Polyclonal (p188) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
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RHOA Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
100 µl/$904
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RHOA Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
100 µl/$904
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RHOA Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
100 µl/$904
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RHOA Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
100 µl/$904
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RHOA Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
100 µl/$904
RHOA Antibody - Anti-RHOA rabbit polyclonal antibody at 1:500 dilution. Lane A: HL60 Whole Cell Lysate. Lane B: MCF7 Whole Cell Lysate. Lane C: HeLa Whole Cell Lysate. Lane D: SKBR3 Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 22 kDa. Observed band size: 18 kDa.
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RHOA Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, IP, WB
Unconjugated, Preservative Free
100 µl/$412
RHOA Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using RhoA Antibody. The picture on the right is blocked with the synthesized peptide.
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RHOA Rabbit anti-Human Polyclonal (aa144-193) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
RHOA Antibody - IHC of Rho A (R182) pAb in paraffin-embedded human breast carcinoma tissue.
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RHOA Rabbit anti-Human Polyclonal (Arg182) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
RHOA Antibody - Immunohistochemical analysis of RhoA staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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RHOA Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Dog, Bovine, Human
IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
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RHOA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
RHOA Antibody - Western blot of RhoA expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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RHOA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).