Rho Kinase / ROCK1

Rho-associated, coiled-coil containing protein kinase 1

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

Rho Kinase / ROCK1 (4)

Publications

No (4)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Mouse (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Rho Kinase / ROCK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115988

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

158.6 kDa

Price:

100 µg/$710

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Mouse Rho Kinase / ROCK1 Protein (Recombinant 6His, N-terminus) (aa1094-1323) - LS-G25506

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

29.9 kDa

Price:

10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192

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Human Rho Kinase / ROCK1 Protein (Recombinant GST, N-terminus) (aa401-510) - LS-G59930

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human Rho Kinase / ROCK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81575

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

158.6 kDa

Price:

20 µg/$215

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