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The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Name: | Rh blood group, D antigen |
Synonyms: | RHD, Blood group Rh(D) polypeptide, CD240D antigen, D antigen (DCS), RH, Rh blood group, D antigen, RHDVA(TT), Rhesus D antigen, RHXIII, Rh polypeptide 2, RH30, Rh30a, Rh4, RhDCw, RHDel, RhK562-II, RHPII, CD240D, DIIIc, Rh blood group antigen Evans, RHCED, Rhesus blood group, D antigen, Rhesus system D polypeptide, RhII, RHPI |
Target Sequences: | NM_016124 NP_057208.2 Q02161 |
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