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RGS13 is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.
Gene Name: | regulator of G-protein signaling 13 |
Family/Subfamily: | Regulator of G-protein signalling , not assigned-Regulator of G-protein signalling |
Synonyms: | RGS13 |
Target Sequences: | AF030107 O14921 O14921 |
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