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RFX2
regulatory factor X, 2 (influences HLA class II expression)
RFX2 is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.
| Gene Name: | regulatory factor X, 2 (influences HLA class II expression) |
| Synonyms: | RFX2, DNA-binding protein RFX2, Regulatory factor X 2, Dna binding protein rfx2 |
| Target Sequences: | NM_000635 NP_000626.2 P48378 |
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