RFWD2 / COP1

ring finger and WD repeat domain 2, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation.

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Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

RFWD2 / COP1 (8)

Publications

No (8)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

Myc-DDK (Flag) (6)

Species

Human (6)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human RFWD2 / COP1 Protein (Recombinant 6His, N-terminus) (aa1-731) - LS-G56040

Source:

E. coli

Tag:

6His, N-terminus

Price:

100 µg/$1,128; 20 µg/$721

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Human RFWD2 / COP1 Protein (Recombinant GST, N-terminus) (aa632-731) - LS-G63085

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RFWD2 / COP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70455

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.3 kDa

Price:

20 µg/$1,107

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Human RFWD2 / COP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70456

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.5 kDa

Price:

20 µg/$1,107

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Human RFWD2 / COP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87140

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.5 kDa

Price:

20 µg/$215

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Human RFWD2 / COP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87141

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.3 kDa

Price:

20 µg/$150

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RFWD2 / COP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110359

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.3 kDa

Price:

100 µg/$494

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RFWD2 / COP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122699

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.5 kDa

Price:

100 µg/$710

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