RFWD2 / COP1

ring finger and WD repeat domain 2, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation.

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Products

Antibodies (28)

Proteins (8)

ELISA Kits (2)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Over-Expression Lysate (4)

Primary (28)

Recombinant (4)

Target

RFWD2 / COP1 (38)

Reactivity

Human (29)

Mouse (21)

Rat (2)

Bat (3)

Bovine (3)

Dog (3)

Gibbon (3)

Guinea pig (3)

Horse (3)

Monkey (3)

Pig (3)

Rabbit (3)

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Application

IHC (1)

WB (27)

ELISA (13)

IF (1)

IP (3)

Peptide-ELISA (4)

Host

rabbit (28)

Isotype

IgG (21)

Clonality

polyclonal pc (28)

Format

96-Well Microplate (2)

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (20)

Epitope

aa672-701 (7)

aa301-350 (4)

pSer387 (3)

330-410 aa (2)

630-710 aa, C-terminal (1)

aa1-50 (1)

aa100-150 (1)

aa353-402 (1)

aa650-699 (1)

aa661-710 (1)

p387 (1)

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Publications

No (38)

Sample Type

Adherent Cell Cultures (2)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

Myc-DDK (Flag) (6)

Species

Human (6)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Purification

Purified (1)

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RFWD2 / COP1 Antibody LS-C805032

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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Human RFWD2 / COP1 Protein (Recombinant 6His, N-terminus) (aa1-731) - LS-G56040

Source:

E. coli

Tag:

6His, N-terminus

Price:

100 µg/$1,128; 20 µg/$721

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RFWD2 / COP1 Antibody LS-C664708

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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RFWD2 / COP1 Antibody (aa672-701) LS-C324630

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal (aa672-701) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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RFWD2 / COP1 Antibody (aa672-701, Biotin) LS-C223874

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal (aa672-701) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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RFWD2 / COP1 Antibody (aa672-701, FITC) LS-C223875

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal (aa672-701) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

RFWD2 / COP1 Antibody (aa672-701, APC) LS-C223873

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal (aa672-701) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

RFWD2 / COP1 Antibody (aa672-701, Azide-free, HRP) LS-C223876

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal (aa672-701) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

RFWD2 / COP1 Antibody (aa672-701, PE) LS-C223877

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal (aa672-701) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

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RFWD2 / COP1 Antibody (630-710 aa, C-terminal) LS-C382849

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal (630-710 aa, C-terminal) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

RFWD2 / COP1 Antibody (330-410 aa) LS-C381073

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal (330-410 aa) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

RFWD2 / COP1 Antibody (330-410 aa) LS-C382847

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal (330-410 aa) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

RFWD2 / COP1 Antibody LS-C824063

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

RFWD2 / COP1 Antibody (phospho-Ser387) LS-C825616

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal (pSer387) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

RFWD2 / COP1 Antibody (p387) LS-C825617

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal (p387) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

RFWD2 / COP1 Antibody (aa1-50) LS-C287734

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

RFWD2 / COP1 Antibody (aa353-402) LS-C291251

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal (aa353-402) Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

RFWD2 / COP1 Antibody (phospho-Ser387) LS-C368786

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal (pSer387) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

30 µl/$263; 100 µl/$315; 200 µl/$379

Select

RFWD2 / COP1 Antibody (phospho-Ser387) LS-C199537

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal (pSer387) Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

RFWD2 / COP1 Antibody (aa650-699) LS-C200590

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal (aa650-699) Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

RFWD2 / COP1 Antibody (aa661-710) LS-C119935

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal (aa661-710) Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

RFWD2 / COP1 Antibody (aa301-350) LS-C145205

Antibody:

RFWD2 / COP1 Rabbit anti-Mouse Polyclonal (aa301-350) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

RFWD2 / COP1 Antibody (aa672-701) LS-C155989

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal (aa672-701) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

RFWD2 / COP1 Antibody LS-C497172

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

RFWD2 / COP1 Antibody LS-C760948

Antibody:

RFWD2 / COP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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