RFFL

ring finger and FYVE-like domain containing E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SNF. May also play a role in endocytic recycling.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

RFFL (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human RFFL Protein (Recombinant GST, N-terminus) (aa2-99) - LS-G63589

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RFFL Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70504

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.3 kDa

Price:

20 µg/$1,107

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Human RFFL Protein (Recombinant GST) (Full Length) - LS-G36289

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

63 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RFFL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87268

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.3 kDa

Price:

20 µg/$150

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RFFL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107980

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.3 kDa

Price:

100 µg/$494

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