RFFL

ring finger and FYVE-like domain containing E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SNF. May also play a role in endocytic recycling.

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Products

Antibodies (23)

Proteins (5)

Type

Over-Expression Lysate (2)

Primary (23)

Recombinant (3)

Target

RFFL (28)

Reactivity

Human (22)

Mouse (9)

Rat (5)

Bovine (3)

Chimpanzee (3)

Gibbon (6)

Guinea pig (3)

Horse (6)

Monkey (6)

Rabbit (3)

Application

IHC (4)

IHC-P (3)

WB (19)

ELISA (10)

IF (3)

Host

rabbit (23)

Product Group

IHCPlus (1)

Isotype

IgG (14)

Clonality

polyclonal pc (23)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Unconjugated (12)

Epitope

aa265-294 (7)

N-Terminus (4)

aa287-336 (4)

Publications

No (28)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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IHC-plus™ RFFL Antibody LS-B416

(4.0) Rating

Antibody:

RFFL Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$535

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RFFL Antibody LS-C334750

Antibody:

RFFL Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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RFFL Antibody LS-C676386

Antibody:

RFFL Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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RFFL Antibody LS-C676385

Antibody:

RFFL Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

Select

RFFL Antibody (aa265-294) LS-C324626

Antibody:

RFFL Rabbit anti-Human Polyclonal (aa265-294) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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RFFL Antibody (aa265-294, Biotin) LS-C223868

Antibody:

RFFL Rabbit anti-Human Polyclonal (aa265-294) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

RFFL Antibody (aa265-294, FITC) LS-C223869

Antibody:

RFFL Rabbit anti-Human Polyclonal (aa265-294) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

RFFL Antibody (aa265-294, APC) LS-C223867

Antibody:

RFFL Rabbit anti-Human Polyclonal (aa265-294) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

RFFL Antibody (aa265-294, PE) LS-C223871

Antibody:

RFFL Rabbit anti-Human Polyclonal (aa265-294) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

RFFL Antibody (aa265-294, Azide-free, HRP) LS-C223870

Antibody:

RFFL Rabbit anti-Human Polyclonal (aa265-294) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

RFFL Antibody LS-C753828

Antibody:

RFFL Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

RFFL Antibody LS-C748645

Antibody:

RFFL Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

RFFL Antibody LS-C833143

Antibody:

RFFL Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

RFFL Antibody (N-Terminus) LS-C146328

Antibody:

RFFL Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

RFFL Antibody (N-Terminus, HRP) LS-C444494

Antibody:

RFFL Rabbit anti-Mouse Polyclonal (N-Terminus) (HRP) Antibody

Reactivity:

Mouse, Guinea pig, Bovine, Horse, Gibbon, Human, Monkey

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

RFFL Antibody (N-Terminus, Biotin) LS-C444491

Antibody:

RFFL Rabbit anti-Mouse Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Mouse, Guinea pig, Bovine, Horse, Gibbon, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

RFFL Antibody (N-Terminus, FITC) LS-C444492

Antibody:

RFFL Rabbit anti-Mouse Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Mouse, Guinea pig, Bovine, Horse, Gibbon, Human, Monkey

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

RFFL Antibody (aa287-336) LS-C116223

Antibody:

RFFL Rabbit anti-Human Polyclonal (aa287-336) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

RFFL Antibody (aa287-336, HRP) LS-C444496

Antibody:

RFFL Rabbit anti-Human Polyclonal (aa287-336) (HRP) Antibody

Reactivity:

Rabbit, Mouse, Rat, Horse, Gibbon, Chimpanzee, Human, Monkey

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

RFFL Antibody (aa287-336, Biotin) LS-C444493

Antibody:

RFFL Rabbit anti-Human Polyclonal (aa287-336) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Rat, Horse, Gibbon, Chimpanzee, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

RFFL Antibody (aa287-336, FITC) LS-C444495

Antibody:

RFFL Rabbit anti-Human Polyclonal (aa287-336) (FITC) Antibody

Reactivity:

Rabbit, Mouse, Rat, Horse, Gibbon, Chimpanzee, Human, Monkey

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

RFFL Antibody (aa265-294) LS-C155984

Antibody:

RFFL Rabbit anti-Human Polyclonal (aa265-294) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

RFFL Antibody LS-C834352

Antibody:

RFFL Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

Human RFFL Protein (Recombinant GST, N-terminus) (aa2-99) - LS-G63589

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human RFFL Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70504

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.3 kDa

Price:

20 µg/$1,107

Viewing 1-25 of 28 product results

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