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RFC2 / RFC40

replication factor C (activator 1) 2, 40kDa

RFC2 / RFC40 is a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2.

Gene Name: replication factor C (activator 1) 2, 40kDa
Synonyms: RFC2, A1 40 kDa subunit, Activator 1 40 kDa subunit, Activator 1 subunit 2, Replication factor C 2, Rfc40, Replication factor C subunit 2, RF-C 40 kDa subunit
Target Sequences: NP_002905.2 P35250

Publications (1)

1
Down-regulation of replication factor C-40 (RFC40) causes chromosomal missegregation in neonatal and hypertrophic adult rat cardiac myocytes. Ata H, Shrestha D, Oka M, Ochi R, Jong CJ, Gebb S, Benjamin J, Schaffer S, Hobart HH, Downey J, McMurtry I, Gupte R. PloS one. 2012 7:e39009. [PubMed:22720015] [PMC:PMC3375256] Related Antibodies: LS-C97283.

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Proteins (9)
Over-Expression Lysate (4)
Recombinant (5)
RFC2 / RFC40 (9)
No (9)
GST (1)
GST, N-terminus (1)
His, N-Terminal (2)
Myc-DDK (Flag) (5)
Human (6)
Mouse (1)
293T Cells (2)
E. coli (2)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purified (1)
RFC2 / RFC40 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
39 kDa
100 µg/$494
RFC2 / RFC40 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
35.1 kDa
100 µg/$494
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293T Cells
Myc-DDK (Flag)
35.1 kDa
20 µg/$150
RFC2 / RFC40 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
39 kDa
20 µg/$150
RFC2 / RFC40 Protein - Recombinant Replication Factor C2 (RFC2) by SDS-PAGE
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E. coli
His, N-Terminal
34.5kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
RFC2 / RFC40 Protein - Recombinant Replication Factor C2 (RFC2) by SDS-PAGE
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E. coli
His, N-Terminal
34.4kDa
10 µg/$271; 50 µg/$382; 200 µg/$762; 100 µg/$610; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
RFC2 / RFC40 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
RFC2 / RFC40 Protein - Purified recombinant protein RFC2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
35.1 kDa
20 µg/$1,107
RFC2 / RFC40 Protein - 12.5% SDS-PAGE of human RFC2 stained with Coomassie Blue
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Wheat Germ Extract
GST
60.83 kDa
10 µg/$479; 25 µg/$670
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).