RET

ret proto-oncogene

Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.

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Products

Antibodies (106)

Proteins (12)

ELISA Kits (10)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Competitive EIA (2)

Custom (3)

Over-Expression Lysate (4)

Primary (106)

Recombinant (8)

Sandwich (2)

Target

RET (128)

Reactivity

Human (101)

Mouse (29)

Rat (26)

All species (8)

Bat (3)

Bovine (3)

Chicken (3)

Chimpanzee (3)

Gibbon (3)

Monkey (6)

Orangutan (3)

Pig (3)

Rabbit (3)

Xenopus (3)

Zebrafish (3)

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Application

IHC (54)

IHC-P (24)

WB (95)

Flo (8)

ELISA (44)

ICC (12)

IF (15)

IP (9)

Peptide-ELISA (8)

SDS-PAGE (1)

Host

rabbit (74)

mouse (30)

goat (2)

Product Group

IHCPlus (2)

PathPlus Neuro (2)

Isotype

IgG (47)

IgG1 (25)

IgG1,k (1)

IgG2a,k (1)

IgG2b (2)

IgM,k (1)

Clonality

monoclonal mc (31)

polyclonal pc (75)

Clone

009 (1)

1A5 (1)

421R25 (1)

6E4C4 (1)

8D10C9 (1)

OTI1G1 (2)

OTI20B8 (2)

OTI21H4 (2)

OTI21H5 (2)

OTI2B3 (2)

OTI2G6 (2)

OTI4H3 (2)

OTI5C5 (2)

OTI5C7 (2)

OTI5D4 (2)

OTI5F2 (2)

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Format

96-Well Microplate (3)

96-Well Strip Plate (6)

AP Conjugated (1)

APC (1)

APC Conjugated (6)

Azide-free (4)

Biotin Conjugated (6)

Carrier-free (11)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (7)

HRP Conjugated (6)

PE Conjugated (5)

Preservative Free (1)

Unconjugated (73)

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Epitope

aa713-1017 (22)

aa1012-1042 (7)

aa1063-1093 (7)

aa13-44 (7)

aa152-182 (7)

pTyr1062 (5)

aa867-916 (4)

pTyr905 (3)

850-930 aa (2)

C-Terminus (2)

Extracellular Domain (2)

aa29-300 (2)

aa896-1063 (2)

pTyr1015 (2)

1010-1090 aa (1)

960-1040 aa (1)

aa1041-1090 (1)

aa881-930 (1)

p1062 (1)

p905 (1)

pY1062 C-Terminus (1)

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Publications

No (128)

Sample Type

Adherent Cell Cultures (3)

Cell Culture Supernatants (2)

Cell Lysates (1)

Heparin Plasma (1)

Plasma (3)

Serum (4)

Tissue Homogenates (2)

Tag

DDK (Flag)-His, C-terminus (1)

DDK,C-terminus (2)

GST (1)

GST, N-terminus (1)

His (1)

His,N-terminus (1)

His-GST (1)

Myc-DDK (Flag) (4)

Species

Human (10)

Source

293T Cells (2)

Baculovirus (1)

HEK 293 Cells (4)

Human Cells (1)

Sf9 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (3)

Select

PathPlus™ RET Antibody (aa1012-1042) LS-B6923

Neuroscience

(5.0) Rating

Antibody:

RET Rabbit anti-Human Polyclonal (aa1012-1042) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

Select

RET Antibody LS-C75422

Antibody:

RET Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, WB

Format:

Unconjugated

Price:

100 µg/$951; 500 µg/$1,795

Select

RET Antibody (phospho-Tyr1062) LS-C117472

Antibody:

RET Rabbit anti-Human Polyclonal (pTyr1062) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

RET Antibody (aa13-44) LS-C99120

Antibody:

RET Rabbit anti-Human Polyclonal (aa13-44) Antibody

Reactivity:

Human

Applications:

Flo, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

RET Antibody (phospho-Y1062 C-Terminus ) LS-C358281

Antibody:

RET Rabbit anti-Human Polyclonal (pY1062 C-Terminus ) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$315

Select

RET Antibody LS-C162547

Antibody:

RET Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.1 ml/$393

Select

IHC-plus™ RET Antibody (aa152-182) LS-B6584

(4.0) Rating

Antibody:

RET Rabbit anti-Human Polyclonal (aa152-182) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

Select

Mouse/Human/Rat Phospho-RET (Tyr1062) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1615

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

RET Antibody (aa896-1063, clone 8D10C9) LS-C41512

Antibody:

RET Mouse anti-Human Monoclonal (aa896-1063) (8D10C9) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$467

Select

IHC-plus™ RET Antibody LS-B16437

(4.0) Rating

Antibody:

RET Goat anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µg/$460

Select

RET Antibody (APC) LS-C75423

Antibody:

RET Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Human

Applications:

Flo

Format:

APC Conjugated

Price:

100 µl/$1,849

Select

RET Antibody (C-Terminus) LS-C358278

Antibody:

RET Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

Select

RET Antibody (C-Terminus) LS-C358277

Antibody:

RET Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

Select

RET Antibody (p905) LS-C826868

Antibody:

RET Rabbit anti-Human Polyclonal (p905) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

Human RET Protein (Recombinant His,N-terminus) (Met1-Arg635) - LS-G47754

Source:

HEK 293 Cells

Tag:

His,N-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human RET consists of 618 amino acids and has a calculated molecular mass of 69.1 kDa. The apparent molecular mass of the protein is approximately 110-120 kDa in SDS-PAGE under reducing conditions.

Price:

50 µg/$441; 1 mg/$2,003

Select

PathPlus™ RET Antibody (clone 1A5) LS-B10954

Neuroscience

(5.0) Rating

Antibody:

RET Mouse anti-Human Monoclonal (1A5) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$440

Select

RET Antibody (phospho-Tyr1062) LS-C192207

Antibody:

RET Rabbit anti-Human Polyclonal (pTyr1062) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$328; 100 µl/$419

Select

RET Antibody (clone 009, Preservative Free) LS-C820664

Antibody:

RET Rabbit anti-Human Monoclonal (Preservative Free) (009) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

Select

RET Antibody (aa881-930) LS-C199525

Antibody:

RET Rabbit anti-Human Polyclonal (aa881-930) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

RET Antibody (850-930 aa) LS-C385853

Antibody:

RET Rabbit anti-Human Polyclonal (850-930 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

RET Antibody (aa13-44) LS-C324625

Antibody:

RET Rabbit anti-Human Polyclonal (aa13-44) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

RET Antibody (aa13-44, PE) LS-C239940

Antibody:

RET Rabbit anti-Human Polyclonal (aa13-44) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• PE

• Unconjugated
• PE

Select

RET Antibody (aa29-300) LS-C376494

Antibody:

RET Rabbit anti-Human Polyclonal (aa29-300) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

Select

RET Antibody (aa713-1017, clone OTI1G1, Carrier-free) LS-C790697

Antibody:

RET Mouse anti-Human Monoclonal (aa713-1017) (Carrier-free) (OTI1G1) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

Select

RET Antibody (aa713-1017, clone OTI5C5, Carrier-free) LS-C790700

Antibody:

RET Mouse anti-Human Monoclonal (aa713-1017) (Carrier-free) (OTI5C5) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

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