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RELN / Reelin

reelin

Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.

Gene Name: reelin
Synonyms: RELN, LIS2, PRO1598, Reelin, RL
Target Sequences: NM_005045 NP_005036.2 P78509

Publications (3)

1
Kainic Acid-Induced Golgi Complex Fragmentation/Dispersal Shifts the Proteolysis of Reelin in Primary Rat Neuronal Cells: An In Vitro Model of Early Stage Epilepsy. Kaneko Y, Sullivan R, Dailey T, Vale FL, Tajiri N, Borlongan CV. Molecular neurobiology. 2016 53:1874-1883. (WB) [Full Text Article] [PubMed:25790952] [PMC:PMC4577368]
2
Rare RELN variants affect Reelin-DAB1 signal transduction in autism spectrum disorder. Sandra M Sánchez-Sánchez, Juliana Magdalon, Karina Griesi-Oliveira, Guilherme L Yamamoto, Carolina Santacruz-Perez, Mariana Fogo, Maria Rita Passos-Bueno, Andrea L Sertié. Human mutation. 2018 October;39:1372-1383. [Full Text Article] [PubMed:29969175]
3
Circulating Reelin promotes inflammation and modulates disease activity in acute and long COVID-19 cases. Laurent Calvier, Aleksandra Drelich, Jason Hsu, Chien-Te Tseng, Yair Mina, Avindra Nath, Maria Z Kounnas, Joachim Herz. Frontiers in immunology. 2023 July;14:1185748. [Full Text Article] [PubMed:37441066] [PMC:PMC10333573]

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Products
Proteins (10)
Over-Expression Lysate (2)
Recombinant (8)
RELN / Reelin (10)
No (10)
6His, N-terminus (2)
His (1)
His-S (2)
His-T7 (3)
Myc-DDK (Flag) (2)
Human (7)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (7)
HEK 293 Cells (1)
Yeast (1)
RELN / Reelin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
388.2 kDa
20 µg/$215
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E. coli
6His, N-terminus
29 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
RELN / Reelin Protein - Recombinant Reelin By SDS-PAGE
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E. coli
6His, N-terminus
27.5 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
RELN / Reelin Protein
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Yeast
His
26.9 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
RELN / Reelin Protein - Recombinant Reelin By SDS-PAGE
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E. coli
His-T7
27.3 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
RELN / Reelin Protein - Recombinant Reelin By SDS-PAGE
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E. coli
His-T7
39.9 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
RELN / Reelin Protein - Recombinant Reelin By SDS-PAGE
Select
E. coli
His-S
41.8 kDa
10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192
RELN / Reelin Protein - Recombinant Reelin By SDS-PAGE
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E. coli
His-T7
21.2 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
RELN / Reelin Protein - Recombinant Reelin By SDS-PAGE
Select
E. coli
His-S
29.4 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
RELN / Reelin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
388.2 kDa
100 µg/$710
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).