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RELN / Reelin

reelin

Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.

Gene Name: reelin
Synonyms: RELN, LIS2, PRO1598, Reelin, RL
Target Sequences: NM_005045 NP_005036.2 P78509

Publications (3)

1
Kainic Acid-Induced Golgi Complex Fragmentation/Dispersal Shifts the Proteolysis of Reelin in Primary Rat Neuronal Cells: An In Vitro Model of Early Stage Epilepsy. Kaneko Y, Sullivan R, Dailey T, Vale FL, Tajiri N, Borlongan CV. Molecular neurobiology. 2016 53:1874-1883. (WB) [Full Text Article] [PubMed:25790952] [PMC:PMC4577368]
2
Rare RELN variants affect Reelin-DAB1 signal transduction in autism spectrum disorder. Sandra M Sánchez-Sánchez, Juliana Magdalon, Karina Griesi-Oliveira, Guilherme L Yamamoto, Carolina Santacruz-Perez, Mariana Fogo, Maria Rita Passos-Bueno, Andrea L Sertié. Human mutation. 2018 October;39:1372-1383. [Full Text Article] [PubMed:29969175]
3
Circulating Reelin promotes inflammation and modulates disease activity in acute and long COVID-19 cases. Laurent Calvier, Aleksandra Drelich, Jason Hsu, Chien-Te Tseng, Yair Mina, Avindra Nath, Maria Z Kounnas, Joachim Herz. Frontiers in immunology. 2023 July;14:1185748. [Full Text Article] [PubMed:37441066] [PMC:PMC10333573]

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Products
ELISA Kits (14)
Custom (4)
Sandwich (9)
Sandwich CLIA (1)
RELN / Reelin (14)
Human (4)
Mouse (4)
Rat (4)
Chicken (1)
96-Well Microplate (3)
96-Well Strip Plate (11)
No (12)
Yes (2)
Cell Culture Supernatants (1)
Cell Lysates (2)
Plasma (8)
Serum (8)
Tissue Homogenates (7)
RELN / Reelin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
RELN / Reelin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$730
RELN / Reelin ELISA Kit
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Sandwich
96-Well Microplate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
RELN / Reelin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$748
RELN / Reelin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
RELN / Reelin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$783
RELN / Reelin ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
RELN / Reelin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$871
RELN / Reelin ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
RELN / Reelin ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
RELN / Reelin ELISA Kit
Select
Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$783
RELN / Reelin ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
RELN / Reelin ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
RELN / Reelin ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Rat
1.37 - 1000 pg/ml
Chemiluminescent
Plasma, Serum, Tissue Homogenates
1 Plate/$911
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).