RELB

v-rel avian reticuloendotheliosis viral oncogene homolog B

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52.

☰ Filters

Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

RELB (7)

Publications

No (7)

Tag

10His, N-terminus + Myc, C-terminus (1)

GST (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

E. coli (1)

Human (4)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

Select

Human RELB Protein (Recombinant His-T7) (aa248-492) - LS-G14329

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.3 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

Select

RELB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115259

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62 kDa

Price:

100 µg/$494

Select

E. coli RELB Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (Full Length) - LS-G137187

Source:

E. coli

Tag:

10His, N-terminus + Myc, C-terminus

Molecular Weight:

16.1 kDa

Price:

20 µg/$405; 1 mg/$1,679; 100 µg/$598

Select

Mouse RELB Protein (Recombinant His-T7) (aa176-436) - LS-G14330

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.3 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

Select

Human RELB Protein (Recombinant GST) (Full Length) - LS-G30147

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

88.5 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Human RELB Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67149

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62 kDa

Price:

20 µg/$1,107

Select

Human RELB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79232

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62 kDa

Price:

20 µg/$150

Viewing 1-7 of 7 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.