REL / C-Rel

v-rel avian reticuloendotheliosis viral oncogene homolog

Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.

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ELISA Kits (5)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Sandwich (3)

Target

REL / C-Rel (5)

Reactivity

Human (3)

Mouse (1)

Chicken (1)

Format

96-Well Microplate (2)

96-Well Strip Plate (3)

Publications

No (5)

Sample Type

Adherent Cell Cultures (2)

Plasma (3)

Serum (3)

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Human Phospho-REL / C-Rel (Ser503) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1613

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Human REL / C-Rel (Cell-Based ELISA) ELISA Kit - LS-F2283

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Human REL / C-Rel (Sandwich ELISA) ELISA Kit - LS-F66510

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Chicken REL / C-Rel (Sandwich ELISA) ELISA Kit - LS-F66673

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Mouse REL / C-Rel (Sandwich ELISA) ELISA Kit - LS-F66955

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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