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Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.
Gene Name: | REC8 meiotic recombination protein |
Synonyms: | REC8, Cohesion rec8p, HR21spB, REC8-like 1 (yeast), REC8-like 1, REC8L1, Rec8p, Cohesin Rec8p, REC8 homolog (yeast) |
Target Sequences: | NM_005132 NP_005123.2 O95072 |
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