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Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.
Gene Name: | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase |
Synonyms: | RCHY1, ARNIP, CHIMP, HARNIP, HPirh2, PIRH2E, PIRH2, PIRH2F, PRO1996, RING finger protein 199, Zinc finger protein 363, ZNF363, p53-induced RING-H2 protein, RNF199 |
Target Sequences: | NP_056251.2 Q96PM5 |
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