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Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.
Gene Name: | RNA binding protein with multiple splicing |
Synonyms: | RBPMS, Rbp-ms/type 5, RBP-MS, HERMES |
Target Sequences: | NM_006867 NP_006858.1 Q93062 |
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