Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Name: | RNA binding protein, fox-1 homolog (C. elegans) 1 |
Synonyms: | RBFOX1, A2BP1, 2BP1, Ataxin 2-binding protein 1, A2BP, FOX-1, FOX1, Ataxin-2-binding protein 1, Fox-1 homolog A, HRNBP1 |
Target Sequences: | NM_018723 NP_061193.2 Q9NWB1 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.