RB1 / Retinoblastoma / RB

retinoblastoma 1

Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.

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Proteins (5)

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Recombinant (4)

Target

RB1 / Retinoblastoma / RB (5)

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No (5)

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6His, N-terminus (1)

GST, N-terminus (1)

His (1)

His-GST (1)

Species

E. coli (1)

Human (3)

Rat (1)

Source

E. coli (4)

Wheat Germ Extract (1)

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Purified (2)

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E. coli RB1 / Retinoblastoma / RB Protein - LS-G134038

Source:

E. coli

Tag:

None

Molecular Weight:

110 kDa

Price:

35 µg/$554

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Human RB1 / Retinoblastoma / RB Protein (Recombinant GST, N-terminus) (aa371-470) - LS-G59874

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Rat RB1 / Retinoblastoma / RB Protein (Recombinant 6His, N-terminus) (aa721-919) - LS-G57097

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human RB1 / Retinoblastoma / RB Protein (Recombinant His) (aa753-928) - LS-G13505

Source:

E. coli

Tag:

His

Molecular Weight:

21.4 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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Human RB1 / Retinoblastoma / RB Protein (Recombinant His-GST) (aa639-778) - LS-G13509

Source:

E. coli

Tag:

His-GST

Molecular Weight:

49.2 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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