RB1 / Retinoblastoma / RB

retinoblastoma 1

Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.

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Products

ELISA Kits (17)

Type

Cell-Based (1)

Cell-Based Phosphorylation (6)

Sandwich (10)

Target

RB1 / Retinoblastoma / RB (17)

Reactivity

Human (11)

Mouse (7)

Rat (7)

Chicken (1)

Monkey (2)

Porcine (1)

Rabbit (1)

Sheep (1)

Format

96-Well Microplate (8)

96-Well Strip Plate (9)

Publications

No (17)

Sample Type

Adherent Cell Cultures (7)

Cell Lysates (1)

Plasma (3)

Serum (3)

Tissue Homogenates (2)

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Mouse/Human/Rat Phospho-RB1 / Retinoblastoma / RB (Ser795) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1611

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Human RB1 / Retinoblastoma / RB (Sandwich ELISA) ELISA Kit - LS-F9928

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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Mouse/Human/Rat Phospho-RB1 / Retinoblastoma / RB (Thr826) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1370

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat RB1 / Retinoblastoma / RB (Cell-Based ELISA) ELISA Kit - LS-F2286

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Mouse/Human/Rat Phospho-RB1 / Retinoblastoma / RB (Ser811) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1310

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

Human RB1 / Retinoblastoma / RB (Sandwich ELISA) ELISA Kit - LS-F35690

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Porcine RB1 / Retinoblastoma / RB (Sandwich ELISA) ELISA Kit - LS-F47738

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Chicken RB1 / Retinoblastoma / RB (Sandwich ELISA) ELISA Kit - LS-F47737

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Monkey RB1 / Retinoblastoma / RB (Sandwich ELISA) ELISA Kit - LS-F47739

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Rabbit RB1 / Retinoblastoma / RB (Sandwich ELISA) ELISA Kit - LS-F47740

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Sheep RB1 / Retinoblastoma / RB (Sandwich ELISA) ELISA Kit - LS-F47741

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Sheep

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$691

Select

Monkey RB1 / Retinoblastoma / RB (Sandwich ELISA) ELISA Kit - LS-F47743

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Human RB1 / Retinoblastoma / RB (Sandwich ELISA) ELISA Kit - LS-F27191

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.5 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

Human RB1 / Retinoblastoma / RB (Sandwich ELISA) ELISA Kit - LS-F21193

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Mouse/Human/Rat Phospho-RB1 / Retinoblastoma / RB (Ser780) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1610

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

Mouse/Human/Rat Phospho-RB1 / Retinoblastoma / RB (Ser807) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1612

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

Mouse/Human/Rat Phospho-RB1 / Retinoblastoma / RB (Ser608) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1667

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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