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Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
Gene Name: | retinoic acid receptor, beta |
Family/Subfamily: | NHR , NR1 Thyroid hormone-like |
Synonyms: | RARB, HBV-activated protein, NR1B2, RAR Beta, RAR-beta, RAR beta4, Retinoic acid receptor beta, RAR beta1, RAR beta2, RARbeta, Retinoic acid receptor, beta, RAR beta3, RAR-epsilon, RARb2, RRB2 |
Target Sequences: | NM_000965 NP_000956.2 P10826 |
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