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GRF2 is a human guanine nucleotide releasing protein for Ras protein. It belongs to the adaptor-type Src homology (SH)2-containing molecules. Src homology 2 domains are globular protein modules present in a large variety of functionally distinct proteins. They mediate binding events that control the activity and localization of many proteins involved in the transmission of signals from the cell surface to the nucleus. The mRNAs of these proteins are expressed ubiquitously in human adult and fetal tissues. There is some evidence of alternative splice products in the literature.
Gene Name: | Rap guanine nucleotide exchange factor (GEF) 1 |
Synonyms: | RAPGEF1, C3G, CRK SH3-binding GNRP, GRF2, Protein C3G |
Target Sequences: | NM_005312 NP_005303.2 Q13905 |
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