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Shirley, MA 01464
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20700 44th Avenue W
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RAMP2
receptor (G protein-coupled) activity modifying protein 2
RAMP2 is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.
| Gene Name: | receptor (G protein-coupled) activity modifying protein 2 |
| Synonyms: | RAMP2 |
| Target Sequences: | NM_005854 NP_005845.2 O60895 |
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