RAF1 / RAF

v-raf-1 murine leukemia viral oncogene homolog 1

Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

RAF1 / RAF (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

His-SUMO, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Sf9 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human RAF1 / RAF Protein (Recombinant His-SUMO, N-terminus) (Full Length) - LS-G21115

Source:

E. coli

Tag:

His-SUMO, N-terminus

Molecular Weight:

89 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human RAF1 / RAF Protein (Recombinant GST) (Full Length) - LS-G30097

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

99.5 kDa

Price:

2 µg/$439

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Human RAF1 / RAF Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66803

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.9 kDa

Price:

20 µg/$1,107

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Human RAF1 / RAF Protein (Recombinant His-T7) (aa342-619) - LS-G14881

Source:

E. coli

Tag:

His-T7

Molecular Weight:

35.6 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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Human RAF1 / RAF Protein (Recombinant GST, N-terminus) (aa1-130) - LS-G59857

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RAF1 / RAF Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78523

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.9 kDa

Price:

20 µg/$150

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RAF1 / RAF Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117703

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.9 kDa

Price:

100 µg/$494

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Human RAF1 / RAF Protein (Recombinant His, N-Terminal) - LS-G142326

Source:

Sf9 Cells

Tag:

His, N-Terminal

Molecular Weight:

39 kDa

Price:

20 µg/$677

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