RAF1 / RAF

v-raf-1 murine leukemia viral oncogene homolog 1

Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.

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Products

ELISA Kits (13)

Type

Cell-Based (1)

Cell-Based Phosphorylation (6)

Custom (4)

Sandwich (2)

Target

RAF1 / RAF (13)

Reactivity

Human (9)

Mouse (8)

Rat (8)

Bovine (1)

Chicken (1)

Format

96-Well Microplate (7)

96-Well Strip Plate (6)

Publications

No (13)

Sample Type

Adherent Cell Cultures (7)

Cell Lysates (1)

Plasma (1)

Serum (1)

Tissue Homogenates (1)

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Human RAF1 / RAF (Sandwich ELISA) ELISA Kit - LS-F7688

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$730

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Mouse/Human/Rat Phospho-RAF1 / RAF (Ser296) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1249

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat Phospho-RAF1 / RAF (Ser43) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1347

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat Phospho-RAF1 / RAF (Tyr341) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1216

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat Phospho-RAF1 / RAF (Ser621) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1217

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat Phospho-RAF1 / RAF (Ser642) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1759

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat RAF1 / RAF (Cell-Based ELISA) ELISA Kit - LS-F1910

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Mouse/Human/Rat Phospho-RAF1 / RAF (Ser338) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1609

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse RAF1 / RAF (Custom) ELISA Kit - LS-F65877

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Price:

1 Plate/$669

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Bovine RAF1 / RAF (Custom) ELISA Kit - LS-F65722

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Bovine

Price:

1 Plate/$669

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Chicken RAF1 / RAF (Custom) ELISA Kit - LS-F66189

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Price:

1 Plate/$783

Select

Rat RAF1 / RAF (Custom) ELISA Kit - LS-F66349

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Price:

1 Plate/$669

Select

Human RAF1 / RAF (Sandwich ELISA) ELISA Kit - LS-F66953

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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